Molecular Distinction: The Science of 3’-Deoxyadenosine Structural SuperiorityCordycepin (C??H??N?O?), a rare nucleoside analog, mimics adenosine yet resists degradation due to its 3’-deoxy structure. This enables unique bioactivity: Source: Journal of Biological Chemistry 2023 Advanced Extraction & Verification Patented Purification ProtocolOur vertically integrated process ensures uncompromised quality: Cultivation: Cordyceps militaris grown in controlled bioreactors (ISO 14644-1 Class 8) Extraction: Supercritical CO? + UHPLC isolation (>98% purity) Verification: HPLC-ELSD/PDA: Quantification (1%-99% customizable) LC-MS/MS: Confirms molecular identity (m/z 252.1 → 136.0) NMR: Validates stereochemical purity (¹H/¹³C) Impurity Control Residual solvents: <10ppm (ICH Q3C compliant) Heavy metals: <0.5ppm (Pb/Cd/As/Hg) Mechanisms of Action: Evidence-Based Efficacy Anti-Tumor Activity Cordycepin selectively accumulates in cancer cells via ENT1 transporters, inducing:? Apoptosis: Caspase-3/7 activation (IC?? = 28μM in A549 cells)? Metastasis Suppression: MMP-9 downregulation (72% inhibition at 50μM)In vivo data: 57% tumor volume reduction vs. controls (Zebrafish xenograft model) Immunomodulation · Enhances NK cell activity by 230% (10mg/kg dose in murine models)· Inhibits NLRP3 inflammasome → Reduces cytokine storms Metabolic & Anti-Fatigue Effects · AMPK-mediated glucose uptake ↑ 300% (L6 myotubes)· ATP regeneration ↑ 45% in exhaustive exercise models Stability Engineered for Real-World Performance Challenge: Cordycepin degrades rapidly in heat/pH >7.0Our Solution: Nano-Encapsulation: Chitosan coating extends half-life by 5x Storage Protocol: Formulation Guidance: Compatible with enteric coatings, lipid carriers Technical Specifications Parameter Specification Purity (HPLC-ELSD) 1%, 3%, 5%, 7%, 21%, 50%, 98%+ Appearance White cryst. (≥98%) / Brown pow. (<50%) Solubility DMSO >100mg/ml; Water <1mg/ml Bioactivity AMPK EC?? = 0.8μM Cross-Industry Applications Sector Formula Integration Mechanistic Role Pharma Intermediates Oncolytic drug conjugates Telomerase inhibitor Nutraceuticals Sublingual tablets / Sports gels ATP booster + Anti-fatigue Cosmeceuticals Acne serums (0.5-2%) Anti-inflammatory / Sebum control Animal Health Poultry feed additive (100ppm) Antibiotic alternative Competitive Advantages ? Batch-to-Batch Consistency RSD <2.0% for 98% purity grade (n=20 batches)? Scalable & Compliant· GMP-aligned facility (Weifang Huazhi subsidiary)· Kosher/Halal/ISO 9001 certifications? Research-Ready Support· Free cell-based assay data (e.g., IC?? on 12 lines)· Custom molecular docking studies Download Resources:[? Cordycepin Mechanism of Action Dossier] • [? HPLC/MS Spectral Library]Science you can formulate with. Nature you can trust. Key Differentiators Precision: UHPLC isolation eliminates psoralen-like contaminants Potency: 3D cell-validated bioactivity (vs. 2D industry standard) Partnership: Co-development of cordycepin-derivatives (e.g., Cordycepin-5’-triphosphate)

For over 2,000 years, Astragalus membranaceus (Huangqi) has been revered in Traditional Chinese Medicine as the "Supreme Qi-Tonifying Herb." Modern science now validates its legendary status through cycloastragenol (CAG)—a bioactive tetracyclic triterpenoid that exemplifies nature’s power to combat aging, immune dysfunction, and chronic disease. As a premier manufacturer of plant extracts, we unlock this potent compound using cutting-edge purification technologies to deliver >98% purity for global health innovations. Botanical Origin and Chemical Profile Cycloastragenol is the aglycone of astragaloside IV, isolated from the roots of Astragalus membranaceus (Fisch.) Bge. var. mongholicus. This small molecule (C??H??O?, MW: 490.72) features a unique 9,19-cyclolanostane structure with four hydroxyl groups critical to its bioactivity. Our extraction process preserves its integrity through: Ethanol/water gradient extraction followed by chromatographic purification Strict QC protocols: HPLC-DAD/ELSD validation, NMR and mass spectrometry confirmation7 Stability optimization: -20°C storage in amber vials to prevent degradation Table 1: Key Specifications of Our Cycloastragenol Parameter Specification CAS No. 78574-94-4 / 84605-18-5 Purity ≥98% (HPLC) Appearance White to off-white crystalline powder Storage -20°C, desiccated Biological Activity Telomerase activation, CTSB inhibition Dual Mechanisms of Action: From Telomeres to Tumor Immunity 1. Telomerase Activation & Anti-Aging Effects Cycloastragenol is nature’s first documented telomerase activator. By binding the catalytic site of telomerase reverse transcriptase (TERT), it: Extends telomeres in CD4+/CD8+ T-cells, delaying replicative senescence Upregulates tert and bcl2 mRNA in neuronal cells, protecting against oxidative stress Enhances antiviral immunity by 300% in human T-lymphocytes (in vitro) This mechanism underpins its potential in age-related disorders—from skin rejuvenation to neuroprotection. 2. Immuno-Oncology: Unblocking MHC-I Antigen Presentation Groundbreaking 2022 research revealed cycloastragenol’s cancer-fighting secret: it directly targets cathepsin B (CTSB) at residues A77/G198. This interaction: Blocks MHC-I degradation in lysosomes, increasing tumor antigen presentation Elevates immunogenic genes (*H2-k1*, B2m, CD74) by 3–5-fold per scRNA-seq data Synergizes with anti-PD-1 therapy, shrinking colon tumors by 60% vs. monotherapy in murine models "CAG reshapes the tumor microenvironment—it’s a ‘checkpoint inhibitor enhancer’ for cold tumors." — Journal for Immunotherapy of Cancer, 2022 Applications in Modern Therapeutics Validated in peer-reviewed studies, cycloastragenol holds promise for: Age-delay supplements: Doubles telomerase activity at 1 μM (6-day exposure Oncology adjuvants: 10 mg/kg/day dosing with PD-1 antibodies boosts CD8+ T-cell infiltratio Neuroprotective agents: Induces CREB phosphorylation to alleviate depression-like behaviors Anti-inflammatory formulations: Suppresses NLRP3 inflammasomes in psoriasis models Quality Commitment We ensure pharmaceutical-grade cycloastragenol through: Bioactivity assays: Telomerase activation (TRAP assay), CTSB binding (MST validation) Traceability: Sustainable sourcing from GAP-certified Astragalus farms Scalability: 50–1000 kg batches with COA, stability data, and customs documentation The Future Is Natural Cycloastragenol bridges ancient wisdom and 21st-century science. As clinical trials explore its potential in longevity and combo oncology therapies, we provide the purest, most bioactive CAG to fuel breakthroughs. Partner with us to co-develop formulations that redefine healthspan

For centuries, Psoralea corylifolia (commonly known as Bakuchi) has been revered in Ayurveda and Traditional Chinese Medicine. Today, its potent bioactive compound—Bakuchiol (C??H??O)—stands at the forefront of cutting-edge cosmetic and nutraceutical research. Extracted from the seeds of this resilient legume, Bakuchiol combines ancient wisdom with validated scientific benefits to deliver multifunctional solutions for modern health and beauty challenges. Unlocking Bakuchiol’s Science-Backed Mechanisms 1. Longevity & Cellular Resilience via DAF-16/FOXO PathwayGroundbreaking research reveals Bakuchiol’s profound anti-aging properties. In C. elegans (a model organism for aging studies), Bakuchiol at 37.5 μM extends lifespan by 38% by activating the evolutionarily conserved IIS/DAF-16 pathway. This triggers: Nuclear translocation of DAF-16 (homologous to human FOXO1), enhancing stress-response gene expression. Upregulation of SOD-3 (superoxide dismutase), boosting antioxidant capacity by 2.3× and combating oxidative damage . Dose-dependent protection against heat and ROS-induced stress, independent of gut microbiota. 2. Multi-Targeted Bioactivity for Holistic ApplicationsBakuchiol’s small molecular structure enables versatile interactions with biological targets: Skin Regeneration: Stimulates collagen synthesis, inhibits matrix metalloproteinases (reducing wrinkles), and suppresses tyrosinase (brightening skin). Antimicrobial Action: Disrupts membranes of S. aureus, E. coli, and C. albicans. Anti-Inflammatory & Estrogenic Effects: Modulates TNF-α/IL-1β and shows potential for bone health . Why Purity ≥99% Is Non-Negotiable Raw Psoralea corylifolia extract contains phototoxic furanocoumarins (e.g., psoralen, isopsoralen), which pose significant safety risks. Our advanced purification process ensures: Ultra-Pure Bakuchiol (≥99%): Using low-pressure supercritical CO? extraction followed by ethanol solvent separation, alkali treatment, and dynamic resin chromatography to eliminate allergens and toxins. Zero Residual Solvents: Unlike petroleum ether/acetate methods, our green technology avoids toxic contaminants. Stability & Scalability: Optimized for industrial production without compromising efficacy. Bakuchiol in Modern Applications Sector Benefits Formulations Cosmetics Retinol-alternative (anti-aging, acne control); non-irritating, photo-stable, suitable for sensitive skin Serums, creams, sunscreens Nutraceuticals Antioxidant/anti-inflammatory support; bone health enhancement Capsules, functional foods Clinical Antimicrobial wound care; depigmentation therapy Gels, ointments Commitment to Sustainability & Efficacy Ethical Sourcing: Psoralea corylifolia is not endangered (IUCN status: Least Concern) and is cultivated under strict ecological guidelines. Clinical Validation: Bakuchiol matches retinol’s efficacy in improving skin elasticity and hyperpigmentation, with 44% less irritation in clinical trials. Global Compliance: EU/Korea/Japan-approved cosmetic ingredient; meets ISO 16128 standards for natural origin. Elevate your formulations with Bakuchiol—where nature’s resilience meets precision science. Contact us to integrate this award-winning, clinically proven extract into your next-generation skincare, wellness, or therapeutic products. Learn more about our CO? extraction technology or request a certificate of analysis → References: Biochemical and Biophysical Research Communications (2025); Sytenol® A Dossier; Chinese Pharmacopoeia (2020).

At Nanjing Spring & Autumn Biological Engineering Co., Ltd., we specialize in unlocking the power of nature through advanced extraction technologies. Our recent production of high-purity Xanthohumol, a remarkable bioactive compound derived from hops (Humulus lupulus), exemplifies our commitment to providing premium natural ingredients. Available in specifications ranging from 1%-8% & 98% HPLC, our xanthohumol extract offers significant potential for applications in the burgeoning fields of health, wellness, and pharmaceutical research. Beyond Beer: Xanthohumol's Health-Promoting Profile Traditionally known for giving beer its characteristic bitterness, hops harbor a far more valuable secret: xanthohumol. This prenylated flavonoid is emerging as a superstar in the natural products world due to its exceptionally diverse and potent biological activities: Powerful Antioxidant & Anti-inflammatory Shield: Xanthohumol is a robust scavenger of free radicals, protecting cells from oxidative stress – a key driver of aging and chronic diseases. Its strong anti-inflammatory properties help modulate pathways involved in conditions like arthritis, metabolic syndrome, and neurodegenerative disorders. Metabolic Health Support: Research highlights xanthohumol's potential in managing metabolic health. Studies suggest it can improve insulin sensitivity, support healthy lipid metabolism by influencing cholesterol levels, and aid in weight management, positioning it as a valuable compound for addressing metabolic syndrome and type 2 diabetes. Cancer Chemoprevention & Therapeutic Potential: Perhaps one of its most studied areas, xanthohumol demonstrates compelling chemopreventive effects. It interferes with multiple stages of cancer development: inhibiting carcinogen activation, inducing detoxifying enzymes, arresting cancer cell growth, promoting apoptosis (programmed cell death), and inhibiting angiogenesis (tumor blood vessel formation). Research explores its efficacy against various cancer types, including breast, prostate, colon, and ovarian cancers. Cardiovascular Protection: By improving lipid profiles, reducing inflammation, and preventing oxidative damage within blood vessels, xanthohumol contributes to cardiovascular health, potentially lowering the risk of atherosclerosis and related complications. Neuroprotective Properties: Emerging evidence suggests xanthohumol may protect neurons from damage, reduce neuroinflammation, and combat oxidative stress in the brain. This opens exciting avenues for research into its role in preventing or managing neurodegenerative diseases like Alzheimer's and Parkinson's. Bone Health & Antimicrobial Activity: Xanthohumol shows promise in stimulating bone formation and inhibiting bone resorption, benefiting bone health. It also possesses antimicrobial properties against certain bacteria and viruses. Translating Potential into Products: Applications of Xanthohumol The multifaceted benefits of xanthohumol make it a highly sought-after ingredient for various applications: Dietary Supplements & Nutraceuticals: Formulated into capsules, tablets, or softgels targeting antioxidant support, metabolic health, joint health, liver detoxification, and overall wellness. Functional Foods & Beverages: Incorporated into health-boosting foods and drinks (beyond beer!), such as health bars, functional juices, or fortified dairy products. Cosmeceuticals: Utilized in skincare products for its potent antioxidant and anti-inflammatory effects, protecting skin from environmental damage and aging. Pharmaceutical Research: Serving as a lead compound or active ingredient in the development of novel drugs for cancer prevention/therapy, metabolic disorders, neurodegenerative diseases, and more. Its high purity (like our 98% grade) is crucial for preclinical and clinical research. Nanjing Spring & Autumn Biological Engineering: Your Partner for Premium Xanthohumol Leveraging our expertise in natural plant extraction, Nanjing Spring & Autumn Biological Engineering is proud to offer high-quality Xanthohumol Extract tailored to meet diverse industry needs. Our recent production batch ensures consistent supply of this potent compound in flexible specifications: Standardized Extracts (1% - 8% Xanthohumol): Ideal for cost-effective incorporation into dietary supplements and functional foods where a defined level of activity is required. High-Purity Xanthohumol (98%): Essential for advanced research, pharmaceutical applications, and high-potency formulations demanding the highest concentration of the active compound. We are committed to rigorous quality control, sustainable sourcing, and advanced production techniques to deliver xanthohumol extract that meets the highest standards of purity, efficacy, and safety. Unlock the Potential Xanthohumol represents a prime example of nature's powerful pharmacy. Its extensive range of scientifically validated health benefits positions it at the forefront of innovation in preventive health, wellness products, and next-generation therapeutics. Visit Nanjing Spring & Autumn Biological Engineering Co., Ltd. at www.km-origus.com.cn to explore our capabilities in natural plant extraction and learn more about our premium Xanthohumol Extract and other botanical solutions. Contact us today to discuss your specific requirements and how we can support your product development in health and medicine.

Broccoli (Brassica oleracea var. italica L.), a representative cold-season crop of the Brassicaceae family, has gradually become a research focus in functional foods and agricultural economics due to its rich bioactive compounds and sustainable potential. This article introduces the phytochemical components of broccoli, such as glucosinolates and sulforaphane, and their molecular mechanisms in preventing metabolic diseases and cancer. It also explores the zero-waste conversion pathways of its by-products and their revolutionary significance for the agricultural industry. Origin and Global Spread Originating from the Mediterranean region, broccoli’s global cultivation has expanded in parallel with its excellent nutritional value. As a member of the Brassicaceae family, broccoli is rich in dietary fiber, vitamins (such as Vitamin C and K), and minerals (like selenium). However, its core competitive advantage lies in its unique bioactive compounds, particularly glucosinolates and their hydrolyzed product, sulforaphane. In recent years, the rising incidence of metabolic syndromes (such as diabetes), cardiovascular diseases, and cancer has driven research into the preventive and therapeutic potential of natural products. Meanwhile, efficient utilization of agricultural waste has become a key challenge in achieving sustainability. Broccoli is regarded as a "golden crop" with both health benefits and economic value due to its all-encompassing utility—from edible florets to by-product utilization. Bioactive Compounds and Health Benefits Molecular Mechanism of Glucosinolate-Sulforaphane Axis The glucosinolate content in broccoli varies depending on the cultivar, growing environment, and processing methods, with glucoraphanin being the dominant type. When the plant undergoes mechanical damage or chewing, the endogenous enzyme myrosinase hydrolyzes glucoraphanin into sulforaphane. Sulforaphane, a type of isothiocyanate, activates the Nrf2-Keap1-ARE signaling pathway, inducing the expression of Phase II detoxification enzymes (e.g., glutathione-S-transferase), thereby enhancing cellular antioxidant defense. Diabetes Prevention: Animal studies show that sulforaphane reduces inflammation in pancreatic β-cells via the NF-κB pathway and improves insulin resistance (IR). Clinical studies indicate that daily intake of 100 μmol of sulforaphane can reduce fasting blood glucose levels by 10%-15% in type 2 diabetes patients. Anti-cancer Activity: Sulforaphane regulates epigenetic modifications, such as inhibiting HDAC activity, to restore the expression of tumor suppressor genes. It induces cell cycle arrest (at G2/M phase) and mitochondria-dependent apoptosis in breast cancer and colon cancer cells. Cardiovascular Protection: Its anti-inflammatory properties reduce oxidative damage to the vascular endothelium, inhibit atherosclerotic plaque formation, and regulate lipid metabolism through activation of the AMPK pathway. Dietary Fiber and Low-Calorie Characteristics Broccoli’s high dietary fiber content (approximately 2.6 g/100 g fresh weight) promotes the growth of beneficial gut microbiota and regulates the production of short-chain fatty acids (SCFAs), thereby improving host metabolic homeostasis. Its low-calorie content (approximately 34 kcal/100 g) makes it an ideal component for obesity management diets. Sustainable Conversion and Applications of By-products Development of Agricultural Chemicals The glucosinolates and polyphenols remaining in the stems and leaves of broccoli can be converted into natural pesticides or fungicides through ultrasound-assisted extraction techniques. For instance, stem extracts exhibit up to 70% inhibition of Botrytis cinerea, with no residual toxicity, significantly outperforming traditional chemical pesticides. Green Synthesis of Nanoparticles Reducing agents in the stems and leaves (such as ascorbic acid) can facilitate the reduction of metal ions (Ag?, Fe³?) to generate nanoparticles with antimicrobial or catalytic activity. Research shows that silver nanoparticles (AgNPs) synthesized from broccoli extracts have a minimum inhibitory concentration (MIC) of 25 μg/mL against Escherichia coli. These nanoparticles, when applied in food packaging films, can extend the shelf life of fresh meat by 3-5 days. Functional Foods and Drug Carriers The cellulose and pectin from broccoli by-products can serve as sustained-release carriers for encapsulating probiotics or active pharmaceutical ingredients. For example, microcapsules made from broccoli stem powder can enhance the survival rate of probiotics in gastric acid environments to over 90%. Moreover, sulforaphane precursors in waste parts can be converted through fermentation engineering into high-purity raw materials for cancer adjunctive treatment. Broccoli is not only a nutrient-dense crop but also a bridge between human health and sustainable agriculture.  

FOR IMMEDIATE RELEASENanjing Spring & Autumn Biological Engineering Co., Ltd.  07/07/2025   ?? Premium Nobiletin 98%: Purity Meets Power We are thrilled to announce the successful outbound shipment of our latest batch of Nobiletin 98% (CAS: 478-01-3), a high-purity citrus flavonoid extracted from Citrus nobilis peels. Rigorously tested via HPLC methods, this batch meets international standards for potency, safety, and consistency—ideal for nutraceutical, pharmaceutical, and functional food applications worldwide. ?? Key Product Specifications Parameter Specification Purity ≥98% (HPLC-verified) CAS No. 478-01-3 Molecular Formula C??H??O? Appearance Colorless crystals Melting Point 137-138°C Solubility Insoluble in water; soluble in DMSO, ethanol Storage 2-8°C (dry, airtight) Botanical Source: Peel of Citrus nobilis (Rutaceae family). ?? Proven Bioactivities & Applications Nobiletin 98% delivers multifaceted health benefits, backed by scientific research: Metabolic & Anti-inflammatory Support: Enhances carbohydrate metabolism and reduces inflammation. Cardiovascular Protection: Inhibits blood cell aggregation and thrombus formation. Antimicrobial & Neuroprotective Effects: Exhibits anti-fungal, anti-allergic, and anti-cholinesterase properties. Ideal For: Dietary supplements, functional foods, skincare (antioxidant serums), and pharmaceutical formulations targeting metabolic and age-related concerns. ?? Driving Global Demand for Plant Extracts As the nutraceutical market expands, plant extracts like Nobiletin are gaining traction: China leads in supplying premium botanical ingredients, with over 100+ plant extract varieties exported globally. Demand surges for natural solutions in blood sugar management, anti-aging, and immunity—positioning Nobiletin as a star ingredient. ? Why Choose Our Nobiletin 98%? Traceability & Compliance: Full documentation (COA, HPLC reports) and adherence to international safety protocols. Scalable Supply: Bulk orders (1kg to 50kg) supported with flexible packaging. Sustainable Sourcing: Raw materials ethically harvested from accredited growers. ?? Order Now & Elevate Your Formulations! This batch is ready for immediate dispatch via air/sea freight. Partner with us to integrate this versatile flavonoid into your next breakthrough product!

Nanjing, China – June 27, 2025 – Nanjing Spring & Autumn Biological Engineering Co., Ltd. is pleased to announce its successful participation at CPHI Shanghai, held from June 24th to 26th, 2025. Our team actively engaged with valued existing clients and welcomed numerous promising new domestic prospects at our booth. The event provided an excellent platform to strengthen relationships and showcase our capabilities in the biological engineering sector. We are grateful for the connections made and productive discussions held throughout the exhibition. Nanjing Spring & Autumn looks forward to building on these interactions and continuing to serve the evolving needs of the industry.

NANJING, China – June 6, 2025 – Nanjing Spring & Autumn Biological Engineering Co., Ltd. is excited to announce its participation in the world's leading pharmaceutical trade event, CPHI Shanghai 2025. Mark your calendars! We will be exhibiting from June 24th to 26th, 2025 at the Shanghai New International Expo Centre (SNIEC).Visit us at Booth: E5G56 This premier gathering unites the global pharmaceutical community, and Nanjing Spring & Autumn Biological Engineering looks forward to connecting with industry partners, existing clients, and potential collaborators. Our team will showcase our latest innovative solutions and comprehensive portfolio within the bio-engineering sector. Why Visit Our Booth (E5G56): Discover our expertise in [Briefly specify your specialty, e.g., advanced enzyme technologies, peptide synthesis, high-purity biochemicals, fermentation solutions – Customize as needed]. Explore partnership opportunities tailored to your project requirements. Learn about our commitment to quality standards, R&D innovation, and customer-focused service. Engage directly with our technical specialists and business development team. As a key platform for pharmaceutical sourcing and networking, CPHI Shanghai 2025 offers unparalleled insights into industry advancements. Discover how Nanjing Spring & Autumn Biological Engineering can become your strategic partner. We warmly welcome you to meet us at Booth E5G56! Event Details: Event: CPHI Shanghai 2025 Dates: June 24–26, 2025 Location: Shanghai New International Expo Centre (SNIEC), China Our Booth: E5G56 Learn more about our capabilities: [www.km-origus.com.cn]

Nanjing, China – Nanjing Spring & Autumn Biological Engineering Co., Ltd. is proud to announce the successful attainment of the ISO 9001:2015 Quality Management System certification. This milestone underscores our unwavering commitment to excellence, operational efficiency, and customer satisfaction across our biological engineering solutions. The ISO 9001 certification validates our systematic approach to quality control, continuous improvement, and adherence to international standards. It reflects our dedication to delivering consistent, high-quality products and services to clients worldwide. We extend heartfelt congratulations to our entire team for their rigorous efforts in achieving this globally recognized standard. Nanjing Spring & Autumn remains steadfast in our mission to advance quality-driven innovation in the biotechnology sector.

Nanjing, China  – Nanjing Spring & Autumn Biological Engineering Co., Ltd. proudly announces the successful attainment of Environmental Impact Assessment (EIA) certification, a critical milestone underscoring our dedication to sustainable operations and ecological responsibility. This certification validates our compliance with stringent environmental standards across manufacturing, R&D, and waste management processes. It reflects our proactive approach to minimizing ecological footprints while advancing cutting-edge biological engineering solutions. As an ISO 9001-certified leader in biotechnology, this achievement further demonstrates our integrated commitment to quality, safety, and planetary stewardship. We will continue to innovate responsibly, aligning industrial growth with environmental preservation.

Nanjing, China  – Nanjing Spring & Autumn Biological Engineering Co., Ltd. is honored to announce its official recognition as a Science and Technology Small and Medium-sized Enterprise (SME) by Jiangsu Provincial authorities. This prestigious designation validates our innovative capabilities and technological excellence in the biological engineering sector. As a dual-certified organization (ISO 9001 and EIA) with growing R&D achievements, this status acknowledges our commitment to advancing biotechnological solutions through cutting-edge research and development. It positions us among Jiangsu's most promising technology-driven enterprises, qualifying for enhanced innovation support and policy incentives. This achievement reflects our team's dedication to transforming scientific discovery into industrial applications. We extend gratitude to all employees and partners who contribute to our innovation ecosystem. Nanjing Spring & Autumn remains steadfast in its mission to drive technological progress and sustainable growth within China's biotechnology landscape.

FOR IMMEDIATE RELEASENanjing Spring & Autumn Biological Engineering Co., Ltd. ?? High-Purity Tangeretin 98%: Unlock Advanced Bioactive Benefits We proudly announce the global release of our new batch of Tangeretin 98% (CAS: 481-53-8), a potent citrus flavonoid extracted from Citrus reticulata peels. Rigorously validated by HPLC analysis, this batch exceeds international standards for purity, safety, and efficacy—perfect for nutraceuticals, pharmaceuticals, and functional foods. ?? Key Product Specifications Parameter Specification Purity ≥98% (HPLC-verified) CAS No. 481-53-8 Molecular Formula C??H??O? Appearance Pale yellow crystals Melting Point 127-129°C Solubility Insoluble in water; soluble in DMSO, ethanol Storage 2-8°C (dry, airtight) Botanical Source: Peel of Citrus reticulata (Rutaceae family). ?? Scientifically-Backed Benefits & Applications Tangeretin 98% delivers targeted health benefits supported by research: Neuroprotective & Anti-Cancer: Modulates cellular signaling pathways to inhibit tumor growth and protect neurons. Metabolic & Anti-Inflammatory: Enhances glucose metabolism and reduces pro-inflammatory cytokines. Antioxidant & Antimicrobial: Neutralizes free radicals and inhibits bacterial/fungal activity.Ideal For: Cognitive health supplements, anticancer formulations, anti-aging skincare, and metabolic wellness products. ?? Rising Global Demand for Citrus Flavonoids As natural health solutions surge, Tangeretin emerges as a key ingredient: Global nutraceutical market to reach $722B by 2027 (CAGR 9.2%), driven by demand for evidence-backed botanicals. China supplies >60% of the world’s premium citrus extracts, with Tangeretin demand growing 15% YoY for neurological and metabolic applications. ? Why Partner With Us? Certified Quality: Full traceability with COA, HPLC, MSDS, and ISO/GMP compliance. Bulk Flexibility: 1kg to 500kg orders; custom packaging (foil bags, drums). Sustainable Sourcing: Ethically harvested from audited citrus farms in Nanjing, China. ?? Order Now & Innovate with Confidence! Limited stock available! Contact us today for samples, pricing, and express shipping (air/sea) options. Elevate your next breakthrough formulation with pharmaceutical-grade Tangeretin! Contact: sale05@cqherb.com | +86-18051083338Website: www.km-origus.com.cn

FOR IMMEDIATE RELEASENanjing Spring & Autumn Biological Engineering Co., Ltd. ?? High-Purity Epicatechin: Power Your Formulations with Elite BioactivityWe proudly launch our new batch of Epicatechin ≥98% (CAS: 490-46-0), a clinically revered flavonoid extracted from Camellia sinensis (green tea). Rigorously validated by HPLC, this batch surpasses international purity benchmarks—ideal for nutraceuticals, sports nutrition, and functional foods. ?? Key Product Specifications Parameter Specification Purity ≥98% (HPLC-verified) CAS No. 490-46-0 Molecular Formula C??H??O? Appearance Pale brown crystalline powder Melting Point 240-244°C Solubility Slightly soluble in water; soluble in ethanol, DMSO Storage 2-8°C (dry, protected from light) Botanical Source: Leaves of Camellia sinensis (Theaceae family). ?? Science-Driven Benefits & ApplicationsEpicatechin 98% delivers targeted bioactivity validated by research: Muscle & Metabolic Health: Enhances exercise performance via nitric oxide modulation and AMPK activation. Cardioprotective: Improves endothelial function and reduces oxidative stress in vascular systems. Neuroprotective & Antioxidant: Crosses the blood-brain barrier to combat neuronal degeneration and free radicals.Ideal For: Sports supplements, cardiovascular health formulas, cognitive enhancers, and longevity products. ?? Global Demand for Performance BotanicalsEpicateclin’s role surges as health markets prioritize evidence-backed actives: Global sports nutrition to hit $50B by 2026 (CAGR 8.9%), fueled by demand for natural performance enhancers. Asia supplies >70% of the world’s tea-derived flavonoids, with Epicatechin demand rising 22% YoY for metabolic and geroprotective applications. ? Why Partner With Us? Certified Excellence: Full COA, HPLC, MSDS, ISO 9001/GMP compliance. Scalable Supply: 100g to 100kg orders; custom packaging (aluminum bags, drums). Eco-Conscious Sourcing: Sustainably harvested from Zhejiang tea farms (China). ?? Order Today & Lead the Innovation Wave!Limited quantities available! Contact us for samples, competitive pricing, and global logistics (air/sea). Transform your next product with pharmaceutical-grade Epicatechin! Contact: sale05@cqherb.com | +86-18051083338Website: www.km-origus.com.cn